When you launch a Creative Suite 5 application, the application unexpectedly quits with an error report that is similar to the following: (in the windows error box click on the show error link)

AppName: [application].exe AppVer: [app version] ModName: updaternotifications.dll ModVer: Offset: 0006a8dc

Solution: http://kb2.adobe.com/cps/845/cpsid_84586.html

Too me all day to find this (including completely removing all adobe products from my PC!!)